Analysis of the spatial and dynamical properties of a multiscale model of intestinal crypts
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چکیده
Intestinal crypts are invaginations in the connective tissue of the human intestine and are supposed to be the site in which tumors originate, starting from the alteration of certain genes and pathways [1]. Considering that, so far, only a partial characterization of the key features of intestinal crypts has been accomplished, the in-depth investigation of their structural and dynamical properties is of crucial importance, with particular regard to the emergence and development of colorectal cancer (CRC) [2]. The basic elements involved in the crypt dynamics and the morphology of the crypt are shown in Figure 1.
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تاریخ انتشار 2013